No, unless you have been diagnosed by a doctor to have some kind of disorder or allergy when exposed to some component of the coffee bean. Basically the only difference between caffeinated and decaffeinated is the caffeine. Consumption of decaffeinated appears to be as almost as beneficial as caffeine-containing coffee in regards to health/mortality, according to a large study. Benefits are seen from 1-6 cups/day. Safety questions still linger regarding decaffeinated coffee based on the solvents used in the past to extract only the caffeine component from the beans, but almost all extraction methods now are very clean, “natural” processes. If your coffee is labeled naturally decaffeinated or Swiss-water processed, this is your assurance that no harmful chemicals/solvents are used.